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KMID : 1202020080010010024
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Journal of Korean Thyroid Association
2008 Volume.1 No. 1 p.24 ~ p.28
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The Effect of Fibrin Sealant Spray on the Amount of Wound Drainage after Total Thyroidectomy and Anterior Compartment Neck Dissection
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Kim Min-Beom
Son Young-Ik
Chung Man-Ki
Cho Jae-Keun
Woo Seung-Hoon
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Abstract
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Background and Objectives: The authors aimed to analyze the effect of fibrin sealant spray on the amount of wound drainage in cases of total thyroidectomy (TT) and anterior compartment neck dissection (ACND).
Materials and Methods: After TT and ACND, 80 adult patients were prospectively and randomly assigned into two groups; a fibrin group and a non-fibrin group. In a fibrin group, 2 ml of fibrin sealant (Tissucol? Duo Quick, Baxter AG, Austria) was evenly sprayed over the surgical bed of TT and ACND. In both groups, a closed suction drainage tube was placed and the amount of drainage was checked in every 8 hours until it was removed when the daily drainage amount became less than 10 ml.
Results: The amount of drainage (average±standard deviation) during the first postoperative 8 hours was 43.8±15.9 ml in 40 patients of non-fibrin group and 25.0±12.6 ml in 40 patients of fibrin group, and this difference was statistically significant (p＜0.001). The cumulative drainage amount for the first postoperative day reduced by 37% in fibrin group (62.0±21.3 ml) when compared to that in non-fibrin group (86.1±33.2 ml). But those at the second and third postoperative day were not statistically different between the two groups.
Conclusion: These results suggest that fibrin sealant spray may help to reduce the amount of drainage in an earlier period but not to avoid placing a closed suction drain in cases of TT and ACND regardless of fibrin sealant spray since the first and second 24 hours drainage amount were larger than conventional guide for safe drain removal.
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KEYWORD
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Thyroidectomy, Neck dissection, Fibrin, Drainage
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